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Joint slip investigation based on finite element modelling verified by experimental results on wind turbine

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 341-351 doi: 10.1007/s11709-017-0393-y

Abstract: study, 8 different types of joints are modelled and studied in the finite element program, and the resultsare verified by the experimental results which have been done in the laboratory.

Keywords： Joint slip     cyclic loading     Finite element modelling     Experimental joint behavior     damping ratios (   

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An experimental study on the flexural behavior of heavily steel reinforced beams with high-strength concrete

Yasser SHARIFI, Ali Akbar MAGHSOUDI

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 1,   Pages 46-56 doi: 10.1007/s11709-014-0237-y

Abstract: Present study describes an experimental research on the behavior of high-strength concrete beams in ultimateBased on the obtained results, the behavior of such members is more deeply reviewed.Also a comparison between theoretical and experimental results is reported here.

Keywords： high-strength concrete (HSC) members     flexural behavior     reinforced concrete     experimental results     ultimate    

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Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 903-912 doi: 10.1007/s11684-021-0871-4

Abstract: A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia (Hhcy) and its influencing factors in China. A standardized questionnaire was used to collect information. Hhcy was defined as the level of serum homocysteine (HCY) ≥15.0 µmol/L. The H-type hypertension (HHYP) was defined as hypertension with an elevated serum HCY (≥15.0 µmol/L). Finally, 110 551 residents ≥40 years of age from 31 provinces in the mainland of China were included. Overall, the median serum HCY level was 10.9 µmol/L (interquartile range 7.9–15.1). A total of 28 633 participants (25.9%) were defined as Hhcy. The Hhcy prevalence ranged from 7.9% in Shanghai to 56.8% in Tianjin. The data showed that serum HCY levels were associated with age, male gender, cigarette smoking, hypertension, diabetes, ethnicity, endurance in exercise (inverse), and fruit and vegetable intake (inverse). In addition, 15 486 participants were defined as HHYP, and the rate was 14.0%. HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752 (95% CI 1.338–2.105). The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences, and national strategies should be carried out to further improve the care of patients with Hhcy across China.

Keywords： homocysteine     hyperhomocysteinemia     H-type hypertension     Chinese    

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Theory and practice of turning R & D results into productive force in major equipment

Zhang Xiaolu

Strategic Study of CAE 2011, Volume 13, Issue 8,   Pages 50-54

Abstract: companies, this paper expounds on the theoretical analysis and organizational methods of turning R & D resultsFaced with the widespread problem that putting R & D results into application is both lengthy andresponsibility and research institutes providing support," and explores the mode to promote R & D resultsThe problems in the ownership of research results, reward application and result ratification were analyzed

Keywords： R & D     major equipment     joint work of industry， college and research institute     transformation of results    

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Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 470-474 doi: 10.1007/s11684-009-0077-7

Abstract: The aim of this paper was to observe the clinical effect of gentamycin combined with sodium bicarbonate for the prevention of irinotecan-induced diarrhea. A total of 98 patients with stage IV cancers were recruited and divided into a prevention group (52 patients) and a control group (46 patients). All patients received the chemotherapy including irinotecan. The prevention group received gentamycin and sodium bicarbonate before the use of irinotecan for 4 days; the control group did not receive any prevention. The use of gentamycin and sodium bicarbonate resulted in significantly higher stool pH ( < 0.001), while the incidence of diarrhea by irinotecan was reduced (prevention group 13.70% control group 34.83%; < 0.001). Gentamycin combined with sodium bicarbonate appears to be useful in preventing the diarrhea induced by irinotecan and reducing the dosage of loperamide and fluid replacement.

Keywords： irinotecan     diarrhea     gentamycin     sodium bicarbonate     prevention    

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improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis. Patients were recruited from prospective skin cancer centers and the German national skin cancer registry (ADOReg) of the German Dermatologic Cooperative Oncology Group (DeCOG). Two cohorts were compared: patients with LDT (cohort A, n = 78) versus those without LDT (cohort B, n = 104). Data were analyzed for response to treatment, progression-free survival (PFS), and overall survival (OS). The median OS was significantly longer in cohort A than in cohort B (20.1 vs. 13.8 months; P = 0.0016) and a trend towards improved PFS was observed for cohort A (3.0 vs. 2.5 months; P = 0.054). The objective response rate to any ICB (16.7% vs. 3.8%, P = 0.0073) and combined ICB (14.1% vs. 4.5%, P = 0.017) was more favorable in cohort A. Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM.

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 67-70 doi: 10.1007/s11684-010-0023-8

Abstract: A community-based multi-center randomized controlled trial was conducted to evaluate the effectiveness of blood pressure control for hypertension patients in communities in urban Shanghai by integrated intervention. At present, patients (=1395) from four communities have completed follow-up for one year, including the intervention group (=921) and usual care group (=474). The intervention programs included disease management by a care manager. Blood pressure of each patient was measured regularly. Compared with the control group, the net change of mean systolic blood pressure (SBP) was −6.75 (95% CI: −7.79 to −5.71, <0.001) mmHg, mean diastolic blood pressure (DBP) was −4.29 (95% CI: −5.08 to −3.49, <0.001) mmHg, and mean pulse pressure (PP) was −2.46 (95% CI: −3.50 to −1.43, <0.001) mmHg in the intervention group. The net change extent was larger in patients with regular pharmacological treatment than in those with irregular pharmacological treatment or non-pharmacological treatment. The measures of integrated intervention for hypertension patients in communities can lower significantly not only SBP and DBP, but also PP. It is suggested that measures of integrated intervention can decrease the risk of cardiovascular diseases in hypertension patients.

Keywords： hypertension     community     pharmacological adherence     control of blood pressure    

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Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 101-107 doi: 10.1007/s11684-020-0752-2

Abstract: Primary hypothyroidism commonly occurs after radiotherapy (RT), and coincides with increased circulating thyroid-stimulating hormone (TSH) levels. We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma (HL) in a prospective cohort study. From 1998 to 2001, a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL, scheduled for craniospinal irradiation and mediastinum/neck radiotherapy, respectively, underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of craniospinal iiradiation. From 14 days before and up to the end of radiotherapy, patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3 μIU/mL. During follow-up, blood tests and ultrasound were repeated; primary hypothyroidism was considered an increased TSH level greater than normal range. Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels ˂ 0.3 μIU/mL and well matched for other variables. Twenty years on, hypothyroidism-free survival rates differed significantly, being 60%±15% and 15.6%±8.2% in TSH-suppressed vs. not-TSH suppressed patients, respectively ( =0.001). These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae, but it should be confirmed in a larger cohort.

Keywords： iatrogenic primary hypothyroidism     late effects of radiotherapy     long-term follow-up     medulloblastoma     Hodgkin lymphoma    

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Stiffness analysis and experimental validation of robotic systems

Giuseppe CARBONE

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 2,   Pages 182-196 doi: 10.1007/s11465-011-0221-3

Abstract: Therefore, this paper proposes procedures for carrying out both numerical and experimental estimationsThen, an experimental procedure for the evaluation stiffness performance is proposed as based on a newsoundness and engineering feasibility of both the proposed numerical formulation for stiffness analysis and experimental

Keywords： robotics     stiffness performance     numerical and experimental estimations    

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Numerical simulation and experimental research on the wheel brush sampling process of an asteroid sampler

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11465-022-0732-0

Abstract: contact dynamics model between particles and sampling wheel brushes is established and a simulation and experimentalThe sampling results and the particle stream curves are obtained for the working conditions of differentwheel brush and the driving torque of the wheel brush motor is determined by comparing the simulation resultswith the test results.Results indicate that when the rotating speed of the wheel brush is faster, the sampling efficiency is

Keywords： asteroid sampling     wheel brush sampler     discrete element method     parameter calibration     experimental    

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Industrialization： Extricating Itself from Difficulty by System Building

Guo Lihong

Strategic Study of CAE 2002, Volume 4, Issue 1,   Pages 23-25

Abstract:

After the shortage economy by and large come to an end, the most serious shortage China faced in all fields is the shortage of systems. In order to accelerate the application of high and new technology in production and improve China´s economic competitiveness in international market, it is necessary to strengthen the economic restructuring, i.e.the system building.

Keywords： high and new technology     application of research results to production     economic restructuring    

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Numerical and experimental analyses of methane leakage in shield tunnel

Frontiers of Structural and Civil Engineering   Pages 1011-1020 doi: 10.1007/s11709-023-0956-z

Abstract: The results show that the leakage process can be divided into “rapid leakage” and “slight leakage”, dependingBased on the numerical and experimental analysis results, a relationship between the safety level and

Keywords： shield tunnel     harmful gas leakage     numerical analysis     laboratory test    

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Intensity Theory and Test Verification

Liu Dabin,Han Wenba,Cai Bingqing and Han Xiaodong

Strategic Study of CAE 2007, Volume 9, Issue 12,   Pages 44-52

Abstract: A comparative study is developed between the test results of pulling or pressing in single directionIt is shown that the new balance particle intensity theory is more coincident with the test results than

Keywords： intensity theory     test results     yield     stress state    

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An experimental characterization of human torso motion

Daniele CAFOLLA,I-Ming CHEN,Marco CECCARELLI

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 4,   Pages 311-325 doi: 10.1007/s11465-015-0352-z

Abstract:

The torso plays an important role in the human-like operation of humanoids. In this paper, a method is proposed to analyze the behavior of the human torso by using inertial and magnetic sensing tools. Experiments are conducted to characterize the motion performance of the human torso during daily routine operations. Furthermore, the forces acting on the human body during these operations are evaluated to design and validate the performance of a humanoid robot.

Keywords： experimental biomechanics     human torso     analysis     inertial sensor     characterization    

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New experimental technique to determine coal self-ignition duration

ZHANG Xinhai, XI Guang, ZHANG Xinhai

Frontiers in Energy 2008, Volume 2, Issue 4,   Pages 479-483 doi: 10.1007/s11708-008-0058-6

Abstract: An oil-bath programmed temperature experiment device was designed and the experimental condition and
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Title Author Date Type Operation

Joint slip investigation based on finite element modelling verified by experimental results on wind turbine

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Journal Article

An experimental study on the flexural behavior of heavily steel reinforced beams with high-strength concrete

Yasser SHARIFI, Ali Akbar MAGHSOUDI

Journal Article

Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

Journal Article

Theory and practice of turning R & D results into productive force in major equipment

Zhang Xiaolu

Journal Article

Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

Journal Article

improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results

Journal Article

Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

Journal Article

Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Journal Article

Stiffness analysis and experimental validation of robotic systems

Giuseppe CARBONE

Journal Article

Numerical simulation and experimental research on the wheel brush sampling process of an asteroid sampler

Journal Article

Industrialization： Extricating Itself from Difficulty by System Building

Guo Lihong

Journal Article

Numerical and experimental analyses of methane leakage in shield tunnel

Journal Article

Intensity Theory and Test Verification

Liu Dabin,Han Wenba,Cai Bingqing and Han Xiaodong

Journal Article

An experimental characterization of human torso motion

Daniele CAFOLLA,I-Ming CHEN,Marco CECCARELLI

Journal Article

New experimental technique to determine coal self-ignition duration

ZHANG Xinhai, XI Guang, ZHANG Xinhai

Journal Article